Reaktion #1681

Reaktionsgleichung

4-chlorobenzaldehyde

levulenic acid

piperidine

toluene

→

product

Ausbeute 44.0%

3-(4-chlorocinnamoyl)-propionic acid

Ausbeute 44.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a dry 250 ml flask equipped with a magnetic stirrer
2. 2
   TemperaturDean-Stark trap, and reflux condenser
3. 3
   TemperaturThe reaction was refluxed for 3 hours
4. 4
   TemperaturThe reaction was cooled
5. 5
   Sonstigeto yield a reddish-brown liquid which
6. 6
   Sonstigewas triturated with hexane

Vorschrift

To a dry 250 ml flask equipped with a magnetic stirrer, Dean-Stark trap, and reflux condenser was charged 15 g of 4-chlorobenzaldehyde, 12.4 g levulenic acid, 5.7 ml of piperidine, and 100 ml of toluene. The reaction was refluxed for 3 hours, after which no water was observed to azeotrope from the solution. The reaction was cooled and stripped to yield a reddish-brown liquid which was triturated with hexane to yield 11.2 g of product as a yellow solid.

Quelle