Reaktion #1680799

Reaktionsgleichung

Water

HCl

ethyl 8-fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thiophene-2-carboxylate

KOH

→

title compound

Ausbeute 96.0%

8-Fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thiophene-2-carboxylic acid

Ausbeute 96.0%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling in an ice-water bath
2. 2
   Sonstigethe resulting white solid precipitate was collected
3. 3
   Sonstigedried

Vorschrift

To a solution of ethyl 8-fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thiophene-2-carboxylate (2.5 g, 9 mmol) in EtOH (60 mL) was added KOH (0.81 g, 15 mmol). The reaction was stirred at 40° C. overnight. After cooling in an ice-water bath, the mixture was acidified to pH 2-3 with 1 N HCl. Water was added and the resulting white solid precipitate was collected and dried to afford 2.15 g (96%) of the title compound: mp 245° C. (dec.), MS (−) 249 (M−H)−.

Quelle