Reaktion #168064

ord-631fea671fce48ad852454dc53b9314c

Reaktionsgleichung

FC(F)(F)c1ccc(-c2ccc(Cl)nn2)cc1
3-chloro-6-(4-trifluoromethylphenyl)pyridazine
CN1CCC(CN2CCNCC2)CC1
(1-methylpiperidin-4-ylmethyl)piperazine
→
CN1CCC(CN2CCN(c3ccc(-c4ccc(C(F)(F)F)cc4)nn3)CC2)CC1.Cl.Cl
title compound
CN1CCC(CN2CCN(c3ccc(-c4ccc(C(F)(F)F)cc4)nn3)CC2)CC1.Cl.Cl
3-[4-(1-Methylpiperidin-4-ylmethyl)piperazin-1-yl]-6-(4-trifluoromethylphenyl)pyridazine, dihydrochloride

Edukte

FC(F)(F)c1ccc(-c2ccc(Cl)nn2)cc1
3-chloro-6-(4-trifluoromethylphenyl)pyridazine
CN1CCC(CN2CCNCC2)CC1
(1-methylpiperidin-4-ylmethyl)piperazine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by a similar procedure to that described in Example 1, starting from 3-chloro-6-(4-trifluoromethylphenyl)pyridazine and (1-methylpiperidin-4-ylmethyl)piperazine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846677B2uspto-grants-2014_09