Reaktion #168060

ord-50904cf368b4439984b9a46102108419

Reaktionsgleichung

FC(F)(F)c1ccc(-c2ccc(Cl)nc2)cc1
2-chloro-5-(4-trifluoromethylphenyl)pyridine
C1CCN(CCCN2CCNCC2)CC1
1-(3-piperidinopropyl)piperazine
→
Cl.Cl.FC(F)(F)c1ccc(-c2ccc(N3CCN(CCCN4CCCCC4)CC3)nc2)cc1
title compound
Cl.Cl.FC(F)(F)c1ccc(-c2ccc(N3CCN(CCCN4CCCCC4)CC3)nc2)cc1
1-(3-Piperidin-1-ylpropyl)-4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazine, dihydrochloride

Edukte

FC(F)(F)c1ccc(-c2ccc(Cl)nc2)cc1
2-chloro-5-(4-trifluoromethylphenyl)pyridine
C1CCN(CCCN2CCNCC2)CC1
1-(3-piperidinopropyl)piperazine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by a similar procedure to that described in Example 1, starting from 2-chloro-5-(4-trifluoromethylphenyl)pyridine and 1-(3-piperidinopropyl)piperazine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846677B2uspto-grants-2014_09