Reaktion #167917

Reaktionsgleichung

2-bromo-1-phenyl-2-pyrid-4-ylethanone

6-chloropyridazin-3-ylamine

→

6-Chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Sonstigethe solvent is evaporated off under reduced pressure
3. 3
   Extraktionthe product is extracted with ethyl acetate
4. 4
   TrocknenThe organic phases are dried over magnesium sulfate
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

A mixture of 13 g (36.5 mmol) of 2-bromo-1-phenyl-2-pyrid-4-ylethanone (CAS No.: 741633-76-1) and 18.9 g (146 mmol) of 6-chloropyridazin-3-ylamine in 200 mL of ethanol is maintained at 90° C. for 5 hours 30 minutes. After cooling, the solvent is evaporated off under reduced pressure, the medium is taken up in 50 mL of water and the product is extracted with ethyl acetate. The organic phases are dried over magnesium sulfate and then concentrated under reduced pressure.

Quelle