Reaktion #167911

Reaktionsgleichung

tert-butyl {4-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl]pyrid-2-yl}carbamate

hydrochloric acid

→

solid

Ausbeute 94.1%

4-[6-Chloro-2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl]pyrid-2-ylamine

Ausbeute 94.1%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent is evaporated off under reduced pressure
2. 2
   Extraktionthe product is extracted with dichloromethane
3. 3
   FiltrationThe organic phase is filtered on a hydrophobic cartridge
4. 4
   Einengenconcentrated under reduced pressure
5. 5
   SonstigeThe solid obtained
6. 6
   Sonstigeis triturated with diisopropyl ether

Vorschrift

To a suspension of 0.76 g (1.67 mmol) of tert-butyl {4-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl]pyrid-2-yl}carbamate in 8 mL of dichloromethane are added 4 mL (48 mmol) of hydrochloric acid. After stirring for 2 hours at room temperature, the solvent is evaporated off under reduced pressure, the oily residue is taken up with aqueous ammonia and the product is extracted with dichloromethane. The organic phase is filtered on a hydrophobic cartridge and concentrated under reduced pressure. The solid obtained is triturated with diisopropyl ether to give 0.56 g of solid after filtering off and drying under reduced pressure.

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