Reaktion #167905

Reaktionsgleichung

6-chloro-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine

2-benzyloctahydropyrrolo[3,4-c]pyrrole

hydrochloric acid

→

6-(5-Benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine

Lösungsmittel

pentanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe aqueous phase is washed with ethyl acetate

Vorschrift

A mixture of 3.00 g (10.9 mmol) of 6-chloro-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine and 6.6 g (33 mmol) of 2-benzyloctahydropyrrolo[3,4-c]pyrrole in 20 mL of pentanol is heated at 150° C. for 2 days in a reactor. The medium is then poured into aqueous 1N hydrochloric acid solution. The aqueous phase is washed with ethyl acetate and then basified with sodium hydroxide.

Quelle