Reaktion #167633

ord-917fa7097abf466f9640519bf4ee2b13

Reaktionsgleichung

Brc1cncc(N2CC3CC4CC2CN(C4)C3)c1
product
Brc1cncc(N2CC3CC4CC2CN(C4)C3)c1
4-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane
CC(=O)c1ccc(B(O)O)s1
5-acetylthiophen-2-ylboronic acid
→
CC(=O)c1ccc(-c2cncc(N3CC4CC5CC3CN(C5)C4)c2)s1
title compound
CC(=O)c1ccc(-c2cncc(N3CC4CC5CC3CN(C5)C4)c2)s1
1-{5-[5-(1,4-diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]thien-2-yl}ethanone

Edukte

Brc1cncc(N2CC3CC4CC2CN(C4)C3)c1
product
Brc1cncc(N2CC3CC4CC2CN(C4)C3)c1
4-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane
CC(=O)c1ccc(B(O)O)s1
5-acetylthiophen-2-ylboronic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from the product of Example 65A and 5-acetylthiophen-2-ylboronic acid according to General Method B: LC-MS Method D (ESI+) m/z 354.0 (M+H)+, retention time 1.26 minutes.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846661B2uspto-grants-2014_09