Reaktion #1675971

Reaktionsgleichung

1H-pyrazole-4-carboxamide

N-[2-(1-cyclopentylethenyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

→

solid

Ausbeute 97.1%

N-[2-(1-cyclopentylethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Ausbeute 97.1%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationContents were filtered
2. 2
   Einengenconcentrated in vacuo

Vorschrift

A mixture of N-[2-(1-cyclopentylideneethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide trifluoromethyl)-1H-pyrazole-4-carboxamide and N-[2-(1-cyclopentylethenyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide (2.5 g), each prepared using the methods described above, were shaken on a Parr Shaker with 5% Pd/C in ethanol (75 mL) under 60 lbs of H2 overnight. Contents were filtered and concentrated in vacuo leaving a white solid (2.44 g). The solid was recrystallized from EtOAc/hexanes to give the desired compound as a white solid (1.3 g).

Quelle