Reaktion #167452

Reaktionsgleichung

Sodium azide

3-chloro-2,2-dimethyl-propionyl chloride

ethylacetate

→

product

Ausbeute 61.4%

3-Chloro-2,2-dimethyl-propionyl azide

Ausbeute 61.4%

Lösungsmittel

hexane

1,4-dioxane

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe reaction mixture was extracted with diethyl ether
2. 2
   Trocknenthe organic layer was dried over Na2SO4

Vorschrift

Sodium azide (4.64 g, 71.38 mmol) was added to a solution of 3-chloro-2,2-dimethyl-propionyl chloride (I-200a: 6 g, 35.71 mmol) in 1,4-dioxane (15 mL) and water (15 mL). The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (5% ethylacetate in hexane). The reaction mixture was extracted with diethyl ether and the organic layer was dried over Na2SO4 to afford 3.5 g of the product (61.40% yield).

Quelle