Reaktion #167407

Reaktionsgleichung

3,1-Benzothiazol-6-yl-4-trifluoromethyl-imidazolidin-2-one

3-Bromo-pyridine

Cyclohexane-1,2-diamine

potassium phosphate

→

product

Ausbeute 23.8%

1-Benzothiazol-6-yl-3-pyridin-3-yl-4-trifluoromethyl-imidazolidin-2-one

Ausbeute 23.8%

Lösungsmittel

1,4-Dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe same reaction conditions
2. 2
   Sonstigeto afford the crude product
3. 3
   SonstigePurification by column chromatography on silica gel (2% methanol in chloroform)

Vorschrift

Using the same reaction conditions and work up as described in example 1, step-3,1-Benzothiazol-6-yl-4-trifluoromethyl-imidazolidin-2-one (I-170b: 50 mg, 0.174 mmol) was refluxed with 3-Bromo-pyridine (33 mg, 0.209 mmol), copper iodide (3.3 mg, 0.0174 mmol), Cyclohexane-1,2-diamine (6 mg, 0.0522 mmol), potassium phosphate (110 mg, 0.522 mmol) and 1,4-Dioxane (2 mL) at 120° C. for 12 hours to afford the crude product. Purification by column chromatography on silica gel (2% methanol in chloroform) followed by n-pentane washing afforded 15 mg of the product (23.8% yield).

Quelle