Reaktion #167305

Reaktionsgleichung

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

2-bromo-4-chloro-thieno[3,2-c]pyridine

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

Ausbeute 22.2%

1-(4-Chloro-thieno[3,2-c]pyridin-2-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

Ausbeute 22.2%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the crude product
2. 2
   SonstigePurification by column chromatography on silica gel (2% MeOH in CHCl3)

Vorschrift

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 100 mg, 0.5643 mmol) was reacted with 2-bromo-4-chloro-thieno[3,2-c]pyridine (141.3 mg, 0.5643 mmol), 1,4-dioxane (20 mL), copper iodide (10.75 mg, 0.05643 mmol), trans-1,2-diamino cyclohexane (19.38 mg, 0.1693 mmol) and potassium phosphate (299 mg, 1.4108 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in CHCl3) afforded 43 mg of the product (22.16% yield).

Quelle