Reaktion #167289

Reaktionsgleichung

1-naphthalen-2-yl-imidazolidin-2-one

3-bromo-5-methoxy-pyridine

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

Ausbeute 30.3%

1-(5-Methoxy-pyridin-3-yl)-3-naphthalen-2-yl-imidazolidin-2-one

Ausbeute 30.3%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the crude product
2. 2
   SonstigePurification by column chromatography on silica gel (30% EtOAc in hexane)

Vorschrift

Using the same reaction conditions as in Example 79, 1-naphthalen-2-yl-imidazolidin-2-one (I-79b: 112.7 mg, 0.5319 mmol) was reacted with 3-bromo-5-methoxy-pyridine (100 mg, 0.5319 mmol), 1,4-dioxane (5 mL), copper iodide (10.13 mg, 0.05319 mmol), trans-1,2-diamino cyclohexane (18.27 mg, 0.1595 mmol) and potassium carbonate (147.07 mg, 1.0638 mmol) to afford the crude product. Purification by column chromatography on silica gel (30% EtOAc in hexane) afforded 48 mg of the product (30.3% yield).

Quelle