Reaktion #167248

Reaktionsgleichung

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

2-bromo-thiophene

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

Ausbeute 109.3%

1-(4-Methyl-pyridin-3-yl)-3-thiophen-2-yl-imidazolidin-2-one

Ausbeute 109.3%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the crude product
2. 2
   SonstigePurification by column chromatography on silica gel (1% MeOH in DCM)

Vorschrift

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.847 mmol) was reacted with 2-bromo-thiophene (0.08 mL, 0.847 mmol), 1,4-dioxane (10 mL), copper iodide (16.13 mg, 0.0847 mmol), trans-1,2-diamino cyclohexane (0.03 mL) and potassium carbonate (233 mg, 1.694 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in DCM) afforded 240 mg of the product (48.4% yield).

Quelle