Reaktion #167232

Reaktionsgleichung

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

5-bromo-benzo[b]thiophene

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

Ausbeute 10.7%

1-Benzo[b]thiophen-5-yl-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

Ausbeute 10.7%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the crude product
2. 2
   SonstigePurification by column chromatography on silica gel (1% MeOH in chloroform)

Vorschrift

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.847 mmol) was reacted with 5-bromo-benzo[b]thiophene (180.5 mg, 0.847 mmol), 1,4-dioxane (15 mL), copper iodide (16.13 mg, 0.0847 mmol), trans-1,2-diamino cyclohexane (0.03 mL, 0.254 mmol) and potassium carbonate (233.97 mg, 1.694 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in chloroform) afforded 28 mg of the product in (10.69% yield).

Quelle