Reaktion #167210

Reaktionsgleichung

1-pyridin-3-yl-imidazolidin-2-one

5-iodo-benzo[b]thiophene

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

Ausbeute 41.4%

1-Benzo[b]thiophen-5-yl-3-pyridin-3-yl-imidazolidin-2-one

Ausbeute 41.4%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the crude product
2. 2
   SonstigePurification by column chromatography on silica gel (1% MeOH in chloroform)

Vorschrift

Using the same reaction conditions as in Example 1, 1-pyridin-3-yl-imidazolidin-2-one (I-1b: 93.6 mg, 0.5747 mmol) was reacted with 5-iodo-benzo[b]thiophene (150 mg, 0.5747 mmol), 1,4-dioxane (5 mL), copper iodide (10 mg, 0.05747 mmol), trans-1,2-diamino cyclohexane (9 mg, 0.0862 mmol) and potassium carbonate (158.9 mg, 1.149 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in chloroform), afforded 70 mg of the product (41.42% yield).

Quelle