Reaktion #1671975

Reaktionsgleichung

7-([1,3]-Dioxan-2-yl)-5-(5-trifluoromethyl-tetrazol-1-yl)-benzofuran

hydrochloric acid

→

title compound

Ausbeute 75.4%

5-(5-Trifluoromethyl-tetrazol-1-yl)-benzofuran-7-carbaldehyde

Ausbeute 75.4%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was heated
2. 2
   Temperaturto reflux
3. 3
   Temperaturcooled
4. 4
   Einengenconcentrated in vacuo
5. 5
   Waschenthe organic phase washed with 8% sodium bicarbonate solution (3×20 ml)
6. 6
   Sonstigedried
7. 7
   Einengenconcentrated in vacuo
8. 8
   SonstigeThe crude material was purified by FCC
9. 9
   Wascheneluted with dichloromethane-hexane (1:1) to dichloromethane-hexane (2:1)

Vorschrift

7-([1,3]-Dioxan-2-yl)-5-(5-trifluoromethyl-tetrazol-1-yl)-benzofuran (160 mg) was dissolved in tetrahydrofuran (30 ml) and dilute hydrochloric acid (20 ml; 2M). The reaction mixture was heated to reflux and stirred for a total of 3 h, cooled and concentrated in vacuo. The residue was taken up in chloroform (40 ml), and the organic phase washed with 8% sodium bicarbonate solution (3×20 ml), dried and concentrated in vacuo. The crude material was purified by FCC eluted with dichloromethane-hexane (1:1) to dichloromethane-hexane (2:1) to give the title compound (100 mg) as an oil.

Quelle