Reaktion #167176

Reaktionsgleichung

5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester

triethylamine

2-bromo-1-(7-bromo-dibenzofuran-3-yl)-ethanone

→

5-Aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-dibenzofuran-3-yl)-2-oxo-ethyl]ester

Ausbeute 95.7%

Lösungsmittel

acetonitrile

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was evaporated
2. 2
   workup.ADDITIONThe mixture was diluted with EtOAc
3. 3
   Waschenwashed with 1.0 N NaOH solution, water and brine
4. 4
   Trocknenwas dried with sodium sulfate
5. 5
   EinengenConcentration

Vorschrift

To the solution of (s) 5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester (138 mg, 0.5 mmol) and triethylamine (65 μl, 0.47 mmol) in acetonitrile (3 ml) was added slowly a solution of 2-bromo-1-(7-bromo-dibenzofuran-3-yl)-ethanone (143 mg, 0.39 mmol) in DMF (4 ml). The mixture was stirred for 12 hours, and the solvent was evaporated. The mixture was diluted with EtOAc, and washed with 1.0 N NaOH solution, water and brine, and was dried with sodium sulfate. Concentration gave 5-Aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-dibenzofuran-3-yl)-2-oxo-ethyl]ester (210 mg)

Quelle