Reaktion #1671395

Reaktionsgleichung

N-[4-[3-(acetyl-methyl-amino)-phenylsulfamoyl]-phenyl]-acetamide

HCl

→

4-amino-N-(3-methylamino-phenyl)-benzenesulfonamide

Ausbeute 85.7%

Lösungsmittel

NaOH

—

1

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturin reflux for 4 hours
2. 2
   Sonstigethe precipitate which separated
3. 3
   Filtrationwas filtered off
4. 4
   SonstigeAfter drying the material on the suction
5. 5
   Filtrationfilter
6. 6
   Sonstigewas chromatographed on silica gel with 3% methanol with dichloromethane

Vorschrift

2.5 g (0.0069 mol) of N-[4-[3-(acetyl-methyl-amino)-phenylsulfamoyl]-phenyl]-acetamide were dissolved in 1 50 ml of 1N NaOH and boiled in reflux for 4 hours. Subsequently, the pH value was adjusted to 4 with 1N HCl and the precipitate which separated was filtered off. After drying the material on the suction filter was chromatographed on silica gel with 3% methanol with dichloromethane. There were obtained 1.64 g (85%) of 4-amino-N-(3-methylamino-phenyl)-benzenesulfonamide as a yellowish solid; m.p.: 134-135° C.

Quelle