Reaktion #1668424

ord-ce0e68d56bc142749e3c57dc6bbaafb7

Reaktionsgleichung

FC(F)(F)CCc1[nH]nc2ccc(Cl)cc12
FC(F)(F)CCc1[nH]nc2c
CC(Cl)c1cccnc1
CC(Cl)c1cccnc1
→
CC(c1cccnc1)n1nc2ccc(Cl)cc2c1CCC(F)(F)F
CC(c1cccnc1)n1nc2ccc

Edukte

FC(F)(F)CCc1[nH]nc2ccc(Cl)cc12
FC(F)(F)CCc1[nH]nc2ccc(Cl)cc12
CC(Cl)c1cccnc1
CC(Cl)c1cccnc1

Reagenzien

O=C([O-])[O-].[Cs+].[Cs+]
cesium carbonate
[I-].[K+]
potassium iodide

Lösungsmittel

CN(C)C=O
dmf
CN(C)C=O
DMF
CN(C)C=O
DMF

Reaktionsbedingungen

Temperatur
70°CELSIUS

Aufarbeitung

  1. 1
    workup.ALIQUOT
  2. 2
    workup.ADDITIONDilution of the aliquot (2 uL) with DMSO (200 uL).

Quelle

DOI: 10.1016/j.chempr.2024.04.001Fig 7 data from Golden paper