Reaktion #1668074

ord-38a7d939df394553a600e38ef2520130

Reaktionsgleichung

COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@@H](C)OC(C)(C)C
Z-Thr(tBu)-Gln-Asn-Phe-OCH3
→
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)[C@@H](C)OC(C)(C)C
H-Thr(tBu)-Gln-Asn-Phe-OCH3

Edukte

COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@@H](C)OC(C)(C)C
Z-Thr(tBu)-Gln-Asn-Phe-OCH3

Reagenzien

[C].[Pd]
palladium carbon

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe amorphous evaporation residue is used for the next condensation as it

Vorschrift

6.31 g of Z-Thr(tBu)-Gln-Asn-Phe-OCH3 and 700 mg of palladium carbon are hydrogenated together at room temperature in 600 ml of methanol in a shaking vessel. The substance gradually passes into solution. The amorphous evaporation residue is used for the next condensation as it is.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US03934008uspto-grants-1976_01