Reaktion #166738

Reaktionsgleichung

tert-Butyl 4-(3-methyl-5-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)piperazine-1-carboxylate

TFA

→

3-methyl-5-phenyl-4-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine

Ausbeute 120.4%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction was then concentrated to dryness
2. 2
   workup.DISSOLUTIONdissolved in minimal DCM
3. 3
   workup.ADDITIONadded dropwise to a stirring solution of 1M HCl in ether
4. 4
   FiltrationThe solid product was filtered
5. 5
   Waschenwashed with ether
6. 6
   Sonstigedried

Vorschrift

tert-Butyl 4-(3-methyl-5-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)piperazine-1-carboxylate (0.390 g, 0.994 mmol) was placed in DCM (10 mL) at room temperature. TFA (1 mL) was added, and the reaction was stirred at room temperature for 1 hour. The reaction was then concentrated to dryness, dissolved in minimal DCM, and added dropwise to a stirring solution of 1M HCl in ether. The solid product was filtered, washed with ether, and dried to give 3-methyl-5-phenyl-4-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine (0.350 g, 96.4% yield), which was used without further purification.

Quelle