Reaktion #166693

Reaktionsgleichung

tert-Butyl 4-(5-bromo-1H-pyrrolo[2,3-b]pyri din-4-yl)piperazine-1-carboxylate

TFA

dihydrochloride

→

5-bromo-4-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine

Ausbeute 94.9%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated to dryness
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in minimal DCM
3. 3
   workup.ADDITIONadded to a stirring solution of 1M HCl in ether
4. 4
   FiltrationThe resulting solid was collected by filtration
5. 5
   Waschenwashed with ether
6. 6
   Sonstigedried

Vorschrift

tert-Butyl 4-(5-bromo-1H-pyrrolo[2,3-b]pyri din-4-yl)piperazine-1-carboxylate (0.40 g, 1.05 mmol) was placed in DCM (3 mL) at room temperature. TFA (0.3 mL) was then added. The reaction was stirred at room temperature for 1 hour and concentrated to dryness. The resulting residue was dissolved in minimal DCM and added to a stirring solution of 1M HCl in ether. The resulting solid was collected by filtration, washed with ether, and dried to give 5-bromo-4-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine (0.28 g, 94.9% yield) as the dihydrochloride salt.

Quelle