Reaktion #166654

Reaktionsgleichung

4-methyl-2-((4-nitro-3-vinyl-1H-indazol-1-yl)methyl)thiazole

→

3-ethyl-1-((4-methylthiazol-2-yl)methyl)-1H-indazol-4-amine

Ausbeute 83.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was purged with argon
2. 2
   Sonstigepurged with hydrogen gas
3. 3
   FiltrationThe mixture was filtered through glass fiber
4. 4
   Filtrationfilter paper
5. 5
   Waschenwashed with methanol
6. 6
   Einengenconcentrated

Vorschrift

A solution of 4-methyl-2-((4-nitro-3-vinyl-1H-indazol-1-yl)methyl)thiazole (0.249 g, 0.829 mmol) in hot ethanol (8 mL) was purged with argon and treated with Pearlman's catalyst (124 mg). The mixture was purged with argon, purged with hydrogen gas and allowed to stir at ambient temperature under hydrogen gas for 14 hours. The mixture was filtered through glass fiber filter paper, washed with methanol and concentrated to afford 3-ethyl-1-((4-methylthiazol-2-yl)methyl)-1H-indazol-4-amine (187 mg, 83%) as a pale yellow oil.

Quelle