Reaktion #1666435

Reaktionsgleichung

3-(3,4-dichlorobenzoyl)-propionic acid

1-hydrazino-2-hexanol

1-hydrazino-2-butanol

1-hydrazino -2-propanol

3-(p-fluorobenzoyl)-propionic acid

→

3-(3,4-dichlorophenyl)-2-(2-hydroxypropyl)-4,5-dihydropyridazin

3-(3,4-dichlorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin

2-hydroxyhexyl-4,5-dihydropyridazin

Reaktionsbedingungen

Vorschrift

When the above procedure is carried out using equivalent amounts of 3-(p-fluorobenzoyl)-propionic acid and 1-hydrazino-2-hexanol,3-(3,4 dichlorobenzoyl)-propionic acid and 1-hydrazino -2-propanol or 3-(3,4-dichlorobenzoyl)-propionic acid and 1-hydrazino-2-hexanol in place of the 3-(p-chlorobenzoyl)-propionic acid and 1-hydrazino-2-butanol used therein, there is obtained 3-(p-fluorophenyl)-2-(2-hydroxyhexyl-4,5-dihydropyridazin (2H)-3-one(m.p. 75°-77°C) 3-(3,4-dichlorophenyl)-2-(2-hydroxypropyl)-4,5-dihydropyridazin (2H)-3-one (m.p. 108.5° - 100°C) or 3-(3,4-dichlorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin (2H)-3-one(m.p. 80°-81°C) respectively.

Quelle