Reaktion #166411

Reaktionsgleichung

compound 399

9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

→

compound 400

Ausbeute 138.9%

1-oxa-4,9-diazaspiro[5.5]undecan-3-one

Ausbeute 138.9%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Trocknenpalladium hydroxide, 20 wt % pd (dry basis) on carbon, wet (300 mg, 427 μmol)
2. 2
   Sonstigefor 6 days
3. 3
   Filtrationthe mixture was filtered
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To a solution of compound 399 (316.1 mg, 1214 μmol) in ethanol (15 mL) was added palladium hydroxide, 20 wt % pd (dry basis) on carbon, wet (300 mg, 427 μmol). After hydrogenating the reaction mixture at 50 psi for 6 days, the mixture was filtered thru a plug of celite and concentrated in vacuo to give compound 400 (287.0 mg). LCMS-ESI (POS), M/Z, M+1: Found 171.1, Calculated 171.1.

Quelle