Reaktion #1663432

ord-92c1e3e7e8c844cd84ce9c0ca68eed92

Reaktionsgleichung

CCN(CC)C(=O)Cl
diethylcarbamylchloride
NC(=O)SC(C(=O)O)c1ccc(C2CCCCC2)c(Cl)c1
α-carbamylthio-3-chloro-4-cyclohexylphenylacetic acid
CCNC(=O)Cl
ethylcarbamyl chloride
CN(C)C(=O)Cl
dimethylcarbamyl chloride
CCNC(=O)SC(C(=O)O)c1ccc(C2CCCCC2)c(Cl)c1
α-ethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid
CN(C)C(=O)SC(C(=O)O)c1ccc(C2CCCCC2)c(Cl)c1
α-dimethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid
NC(=O)Cl
carbamyl chloride
→
CCN(CC)C(=O)SC(C(=O)O)c1ccc(C2CCCCC2)c(Cl)c1
α-Diethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid

Edukte

CCN(CC)C(=O)Cl
diethylcarbamylchloride
NC(=O)SC(C(=O)O)c1ccc(C2CCCCC2)c(Cl)c1
α-carbamylthio-3-chloro-4-cyclohexylphenylacetic acid
CCNC(=O)Cl
ethylcarbamyl chloride
CN(C)C(=O)Cl
dimethylcarbamyl chloride
CCNC(=O)SC(C(=O)O)c1ccc(C2CCCCC2)c(Cl)c1
α-ethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid
CN(C)C(=O)SC(C(=O)O)c1ccc(C2CCCCC2)c(Cl)c1
α-dimethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid
NC(=O)Cl
carbamyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigethe products prepared

Vorschrift

When diethylcarbamylchloride is replaced in the above procedure by carbamyl chloride (prepared in situ from potassium cyanate and anhydrous hydrogen chloride in anhydrous chloroform), ethylcarbamyl chloride or dimethylcarbamyl chloride, then the products prepared are α-carbamylthio-3-chloro-4-cyclohexylphenylacetic acid, α-ethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid or α-dimethylcarbamylthio-3-chloro-4-cyclohexylphenylacetic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US03979428uspto-grants-1976_09