Reaktion #166221

Reaktionsgleichung

(2-dimethoxymethyl-3-fluoro-6-nitro-phenyl)-(2-fluoro-4-iodo-phenyl)-amine

HCl

→

title compound

Ausbeute 96.3%

6-Fluoro-2-(2-fluoro-4-iodo-phenylamino)-3-nitro-benzaldehyde

Ausbeute 96.3%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter 2 hours the THF was removed in vacuo
2. 2
   workup.ADDITIONthe residue diluted with water (20 ml)
3. 3
   Sonstigeproviding a precipitate
4. 4
   FiltrationThe solid precipitate was collected by filtration
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried under vacuum

Vorschrift

To a stirred solution of (2-dimethoxymethyl-3-fluoro-6-nitro-phenyl)-(2-fluoro-4-iodo-phenyl)-amine (1.0 g, 2.22 mmol) in THF (10 ml) was added a solution of 4M HCl at room temperature. After 2 hours the THF was removed in vacuo and the residue diluted with water (20 ml) providing a precipitate. The solid precipitate was collected by filtration, washed with water and dried under vacuum to yield the title compound (864 mg, 96%). LCMS (Method B): RT=4.06 min, [M−H]−=403.

Quelle