Reaktion #166091

Reaktionsgleichung

Trans-5-amino-2-diphenylmethyl-tetrahydropyran

Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine

4-bromobenzaldehyde

acetic acid

NaCNBH3

→

compound 16l

Ausbeute 80.0%

Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-bromo-benzyl)-amine

Ausbeute 80.0%

Lösungsmittel

1,2-dichloroethane

methanol

Reaktionsbedingungen

Vorschrift

Trans-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.04 g, 0.15 mmol) was reacted with 4-bromobenzaldehyde (0.028 g, 0.15 mmol) in the presence of glacial acetic acid (0.009 g, 0.15 mmol) in 1,2-dichloroethane (20 ml), and NaCNBH3 (0.012 g, 0.18 mmol) in methanol (5 ml) (Procedure D) to give compound 16l (0.052 g, 80%) as an oil.

Quelle