Reaktion #166090

Reaktionsgleichung

Trans-5-amino-2-diphenylmethyl-tetrahydropyran

Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine

benzaldehyde

acetic acid

NaCNBH3

→

compound 16k

Ausbeute 86.5%

Cis-(6-benzhydryl-tetrahydropyran-3-yl)-benzyl-amine

Ausbeute 86.5%

Lösungsmittel

1,2-dichloroethane

methanol

Reaktionsbedingungen

Vorschrift

Trans-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.03 g, 0.11 mmol) was reacted with benzaldehyde (0.012 g, 0.11 mmol) in the presence of glacial acetic acid (0.007 g, 0.11 mmol) in 1,2-dichloroethane (20 ml), and NaCNBH3 (0.009 g, 0.14 mmol) in methanol (5 ml) (Procedure D) to give compound 16k (0.034 g, 85%).

Quelle