Reaktion #166084

Reaktionsgleichung

Trans-5-amino-2-diphenylmethyl-tetrahydropyran

Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine

4-cyanobenzaldehyde

acetic acid

NaCNBH3

→

compound 16c

Ausbeute 80.0%

Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-cyano-benzyl)-amine

Ausbeute 80.0%

Lösungsmittel

1,2-dichloroethane

methanol

Reaktionsbedingungen

Vorschrift

Trans-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.15 g, 0.56 mmol) was reacted with 4-cyanobenzaldehyde (0.07 g, 0.56 mmol) in the presence of glacial acetic acid (0.033 g, 0.56 mmol) in 1,2-dichloroethane (20 ml), and NaCNBH3 (0.042 g, 0.67 mmol) in methanol (5 ml) (Procedure D) to give compound 16c (0.17 g, 80%) as an oil.

Quelle