Reaktion #165958

Reaktionsgleichung

MeOH

dry ice

5-fluoro-2-phenylpyridine

n-butyllithium

→

5-fluoro-2-phenylisonicotinic acid

Ausbeute 58.0%

Lösungsmittel

THF

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGStirred for 1 h
2. 2
   EinengenThe solution was concentrated
3. 3
   Sonstigepurified on Flashmaster II

Vorschrift

To a solution of 5-fluoro-2-phenylpyridine (760.0 mg, 4.39 mmol) in tetrahydrofuran (15.0 ml) was added n-butyllithium (2.11 ml, 2.50 M in THF, 5.27 mmol) at −45° C. The mixture was stirred for 1 h at −45° C., then poured into THF containing dry ice. Stirred for 1 h, then MeOH (2 ml) was added. The solution was concentrated, and purified on Flashmaster II to get 560 mg (58%) of 5-fluoro-2-phenylisonicotinic acid.

Quelle