Reaktion #165928

Reaktionsgleichung

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate

Ethanol

N-bromosuccinimide

→

Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereaction mass
2. 2
   Temperaturby maintaining temp below 10° C
3. 3
   SonstigeReaction mass
4. 4
   SonstigeReaction mass
5. 5
   Waschenwas washed with sodium bicarbonate solution (8%, 3×400 ml)
6. 6
   SonstigeReaction mass
7. 7
   Einengenwas then concentrated to residue

Vorschrift

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (100 g) was dissolved in dichloromethane (500 ml) and Ethanol (150 ml) was added to reaction mass and then reaction mass was cooled to 5 to 10° C. N-bromosuccinimide (115 g) was added lot wise by maintaining temp below 10° C. Reaction mass was then stirred at 20-30° C. till completion of reaction. Reaction mass was washed with sodium bicarbonate solution (8%, 3×400 ml). Reaction mass was then concentrated to residue to get Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 170 g).

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