Reaktion #165885

Reaktionsgleichung

2-hydroxy-4,5-dimethoxybenzoic acid 4-nitrophenyl ester

2-amino-1,3-thiazole-4-carboxylic acid methyl ester

methanol

→

title compound ( 5a )

Ausbeute 84.9%

2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester

Ausbeute 84.9%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas then added
2. 2
   Temperaturby heating
3. 3
   Temperaturto reflux for one hour
4. 4
   SonstigeThe resultant reaction mixture
5. 5
   Temperaturto cool
6. 6
   Sonstigeby collecting the precipitated crystal
7. 7
   Filtrationby filtration at 30° C.
8. 8
   Sonstigelower before drying under reduced pressure

Vorschrift

In 1 mL of xylene were suspended 200 mg of 2-hydroxy-4,5-dimethoxybenzoic acid 4-nitrophenyl ester and 119 mg of 2-amino-1,3-thiazole-4-carboxylic acid methyl ester in a stream of argon, which was then stirred at 130° C. for 12 hours. The reaction mixture was allowed to stand to cool, to which 1 mL of methanol was then added, followed by heating to reflux for one hour. The resultant reaction mixture was allowed to stand to cool, followed by collecting the precipitated crystal by filtration at 30° C. or lower before drying under reduced pressure to provide 180 mg of the title compound (5a) at a yield of 80%.

Quelle