Reaktion #165883

Reaktionsgleichung

SOCl2

compound ( 2a )

2-hydroxy-4,5-dimethoxybenzoic acid

phenol

SOCl2

→

phenyl 2-hydroxy-4,5-dimethoxybenzoate

Ausbeute 64.0%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturbefore heating
2. 2
   Temperaturto reflux for 3 hours
3. 3
   Temperaturadditionally heating
4. 4
   Temperaturto reflux for one hour
5. 5
   workup.DISTILLATIONThe reaction solvent was distilled off
6. 6
   workup.ADDITIONby adding methanol to the residue
7. 7
   FiltrationThe precipitated crystal was collected by filtration

Vorschrift

In 10 g of xylene were suspended 1.0 g of compound (2a) and 522 mg of phenol, to which 460 μL of SOCl2 was then added dropwise before heating to reflux for 3 hours, followed by further adding 184 μL of SOCl2 and additionally heating to reflux for one hour. The reaction solvent was distilled off, followed by adding methanol to the residue before stirring. The precipitated crystal was collected by filtration to provide 880 mg of phenyl 2-hydroxy-4,5-dimethoxybenzoate (3a) at a yield of 64%.

Quelle