Reaktion #165751

Reaktionsgleichung

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

product

Ausbeute 70.0%

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

Ausbeute 70.0%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere added
2. 2
   Sonstigethe solvent was removed in vacuo
3. 3
   Sonstigethe residue triturated with MeOH
4. 4
   FiltrationThe resultant filtrate was filtered off

Vorschrift

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (770 mg, 3.318 mmol) was suspended in DCM (10 mL) and triethylamine (369.3 mg, 508.7 μL, 3.650 mmol) followed by benzoyl chloride (513.1 mg, 423.7 μL, 3.650 mmol) were added. After 1 hour, the solvent was removed in vacuo and the residue triturated with MeOH. The resultant filtrate was filtered off to furnish the product as an off-white solid (779 mg, 70% Yield).

Quelle