Reaktion #165588

Reaktionsgleichung

4,5-dimethylthiazol-2-ylamine

(2-bromo-ethoxy)benzene

→

title compound

Ausbeute 50.6%

4,5-Dimethyl-3-(2-phenoxy-ethyl)-3H-thiazol-2-ylideneamine hydrobromide

Ausbeute 50.6%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to ambient temperature
2. 2
   Sonstigethe residue was crystallized from isopropanol
3. 3
   FiltrationThe solid was collected by filtration
4. 4
   Sonstigedried under vacuum

Vorschrift

A mixture of 4,5-dimethylthiazol-2-ylamine (1.0 g, 7.8 mmol) and (2-bromo-ethoxy)benzene (1.9 g, 9.4 mmol) were heated neat to 85° C. for 19 hours. The mixture was cooled to ambient temperature and the residue was crystallized from isopropanol. The solid was collected by filtration and dried under vacuum to afford 1.3 g (50%) of the title compound. MS (DCI/NH3) m/z 249 (M+H)+.

Quelle