Reaktion #165205

Reaktionsgleichung

4-cyclohexyloxy-benzaldehyde

nitromethane

ammonium acetate

→

title compound

Ausbeute 96.0%

1-Cyclohexyloxy-4-((E)-2-nitro-vinyl)-benzene

Ausbeute 96.0%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThis mixture was cooled to room temperature
2. 2
   Einengenconcentrated under a reduced pressure
3. 3
   workup.ADDITIONdiluted with ethyl acetate
4. 4
   WaschenThe organic layer was washed with saturated aqueous sodium chloride
5. 5
   Trocknendried over anhydrous magnesium sulfate
6. 6
   Filtrationfiltered
7. 7
   EinengenThe filtrate was concentrated under a reduced pressure

Vorschrift

A mixture of 4-cyclohexyloxy-benzaldehyde (2.84 g, 13.9 mmol) described in Manufacturing Example 79-1-1, nitromethane (3.74 mL, 69.5 mmol), ammonium acetate (2.14 g, 27.8 mmol) and acetic acid (30 mL) was stirred for 14 hours at 100° C. This mixture was cooled to room temperature, concentrated under a reduced pressure, and diluted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure to obtain the title compound (3.3 g).

Quelle