Reaktion #165204

Reaktionsgleichung

diethylazodicarboxylate

4-hydroxybenzaldehyde

cyclohexanol

triphenylphosphine

→

title compound

Ausbeute 34.0%

4-Cyclohexyloxy-benzaldehyde

Ausbeute 34.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was concentrated under a reduced pressure
2. 2
   Sonstigethe residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1)

Vorschrift

To a tetrahydrofuran (250 mL) solution of diethylazodicarboxylate (16.1 mL, 40.9 mmol) were added 4-hydroxybenzaldehyde (5 g, 40.9 mmol), cyclohexanol (4.31 mL, 40.9 mmol) and triphenylphosphine (10.7 g, 40.9 mmol). This mixture was stirred for 30 hours at room temperature. The mixture was concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1) to obtain the title compound (2.84 g, 34%).

Quelle