Reaktion #165095

Reaktionsgleichung

methylene chloride

Sodium bicarbonate

(2-Methyl-pyridin-4-yl)-methanol

thionyl chloride

→

4-chloromethyl-2-methyl-pyridine

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto separate the reaction solution
2. 2
   Trocknenthe ethyl acetate layer was dried over sodium sulfate
3. 3
   SonstigeThe solvent was evaporated under a reduced pressure

Vorschrift

(2-Methyl-pyridin-4-yl)-methanol (40 mg, 0.33 mmol) described in Manufacturing Example 47-1-1, thionyl chloride (0.047 ml, 0.65 mmol) and methylene chloride (4.0 ml) were stirred for 5 minutes at 60° C. Sodium bicarbonate solution and ethyl acetate were added to separate the reaction solution, and the ethyl acetate layer was dried over sodium sulfate. The solvent was evaporated under a reduced pressure to obtain 4-chloromethyl-2-methyl-pyridine as a crude product.

Quelle