Reaktion #165052

Reaktionsgleichung

(4-butoxymethyl-phenyl)-methanol

triphenylphosphine

carbon tetrachloride

→

title compound

Ausbeute 86.0%

1-Butoxymethyl-4-chloromethyl-benzene

Ausbeute 86.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 7 hours
2. 2
   Einengenconcentrated under a reduced pressure
3. 3
   SonstigeThe residue was purified by neutral silica gel column chromatography (ethyl acetate:heptane=1:15)

Vorschrift

A mixture of (4-butoxymethyl-phenyl)-methanol (190 mg, 0.98 mmol) described in Manufacturing Example 33-1-3, triphenylphosphine (310 mg, 1.2 mmol) and carbon tetrachloride (3 mL) was stirred under reflux for 7 hours. The reaction mixture was cooled to room temperature, and concentrated under a reduced pressure. The residue was purified by neutral silica gel column chromatography (ethyl acetate:heptane=1:15) to obtain the title compound (180 mg, 86%).

Quelle