Reaktion #165050

Reaktionsgleichung

4-butoxymethyl-benzonitrile

lithium aluminum hydride

ammonia

→

title compound

Ausbeute 101.0%

4-Butoxymethyl-benzylamine

Ausbeute 101.0%

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   TemperaturThe reaction mixture was warmed to room temperature
3. 3
   Filtrationfiltered
4. 4
   EinengenThe filtrate was concentrated under a reduced pressure

Vorschrift

To a mixture of lithium aluminum hydride (600 mg, 13 mmol, purity: 80%) and tetrahydrofuran (10 mL) was added a mixture of 4-butoxymethyl-benzonitrile (600 mg, 3.2 mmol) described in Manufacturing Example 33-1-1 and tetrahydrofuran (10 mL) at 0° C., which was stirred for 4 hours at room temperature. 28% Aqueous ammonia solution was added dropwise to the reaction mixture at 0° C. The reaction mixture was warmed to room temperature and filtered. The filtrate was concentrated under a reduced pressure to obtain the title compound (620 mg, 101%) as a crude product.

Quelle