Reaktion #164910

Reaktionsgleichung

potassium carbonate

6-bromopyridin-2-amine

3-iodo-4-methyl-N-[3-(trifluoromethyl)phenyl]benzamide

potassium acetate

4,4,5,5,4′,4′,5′,5′-octamethyl-[2,2]bi[[1,3,2]dioxaborolanyl]

DCM

→

3-(6-Aminopyridin-2-yl)-4-methyl-N-[3-(trifluoromethyl)phenyl]benzamide

Lösungsmittel

water

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled
2. 2
   SonstigeAfter degassing the mixture, it
3. 3
   SonstigeThe solvent was then removed in vacuo
4. 4
   workup.ADDITIONWater was added
5. 5
   Extraktionthe product was extracted with three portions of ethyl acetate
6. 6
   WaschenThe combined extracts were washed with brine
7. 7
   Trocknendried over sodium sulfate
8. 8
   Einengenconcentrated
9. 9
   SonstigePurification
10. 10
    Wascheneluting with a gradient from 0-50% ethyl acetate in hexanes)
11. 11
    Sonstigeafforded the product

Vorschrift

To a degassed mixture of 3-iodo-4-methyl-N-[3-(trifluoromethyl)phenyl]benzamide (0.500 g, 1.23 mmol), potassium acetate (424 mg, 4.32 mmol), DMF (15 mL), and 4,4,5,5,4′,4′,5′,5′-octamethyl-[2,2]bi[[1,3,2]dioxaborolanyl] (0.329 g, 1.30 mmol) was added [1,1′-bis(diphenylphosphino)-ferrocene]dichloropalladium(II), complex with DCM (1:1) (101 mg, 0.123 mmol). The reaction was heated to 80° C. for 3 hours, at which time conversion to the boronic ester was complete. The mixture was cooled and potassium carbonate (512 mg, 3.70 mmol), water (2.24 mL), and 6-bromopyridin-2-amine (214 mg, 1.23 mmol) were added. After degassing the mixture, it was heated to 85° C. for 1 hour. The solvent was then removed in vacuo. Water was added and the product was extracted with three portions of ethyl acetate. The combined extracts were washed with brine, dried over sodium sulfate, and concentrated. Purification was carried out by flash column chromatography (eluting with a gradient from 0-50% ethyl acetate in hexanes) afforded the product. (254 mg, 50%).

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