Reaktion #164874

Reaktionsgleichung

cyclopropylamine

4-(2-bromoethoxy)biphenyl

→

N-[2-(biphenyl-4-yloxy)ethyl]cyclo-propanamine

Ausbeute 96.3%

Lösungsmittel

tetrahydrofurane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent and the excess of cyclopropylamine are then removed under vacuum
2. 2
   workup.DISSOLUTIONthe residue is dissolved in ethyl acetate
3. 3
   workup.ADDITIONby adding a 1N solution of HCl
4. 4
   FiltrationThe abundant obtained white precipate is filtered
5. 5
   Waschenwashed by water and to diisopropyl ether
6. 6
   Sonstigedried under vacuum

Vorschrift

To a mixture of 5.15 g (90.2 mmol) of cyclopropylamine and 2.5 ml (18.04 mmol) of thiethylamine in 50 ml of tetrahydrofurane is added 5 g (18.04 mmol) of 4-(2-bromoethoxy)biphenyl. The reaction mixture is heated at 50° C. for 5 hrs. The solvent and the excess of cyclopropylamine are then removed under vacuum and the residue is dissolved in ethyl acetate. The organic solution is acidified to pH=4 by adding a 1N solution of HCl. The abundant obtained white precipate is filtered, washed by water and to diisopropyl ether and dried under vacuum to yield 4.4 g (96% yield) of N-[2-(biphenyl-4-yloxy)ethyl]cyclo-propanamine as its hydrochloride salt. mp (melting point)=252° C.

Quelle