Reaktion #164700

Reaktionsgleichung

diethyl ether

N-1-Aza-bicyclo[2.2.2]oct-3-yl-N′-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-N′-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

Intermediate 4

N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-N′-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

benzyl bromide

→

title compound

Ausbeute 57.3%

1-Benzyl-3-[N′-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-azoniabicyclo[2.2.2]octane bromide

Ausbeute 57.3%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe solid collected by filtration
2. 2
   Waschenwashed with diethyl ether
3. 3
   Sonstigedried under vacuum

Vorschrift

N-1-Aza-bicyclo[2.2.2]oct-3-yl-N′-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine (Intermediate 4, 30 mg, 0.089 mmol) and benzyl bromide (Acros, 17 mg, 0.097 mmol) are stirred for 4 h at 70° C. in acetonitrile (2 mL). To the suspension is added diethyl ether (2 mL), the solid collected by filtration, washed with diethyl ether and dried under vacuum to yield the title compound (26 mg).

Quelle