Reaktion #164687

Reaktionsgleichung

hydrochloric acid

methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

methanol

NaOH

→

3,5-Diamino-6-chloropyrazine-2-carboxylic acid

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 3 h
2. 2
   SonstigeThe precipitate formed
3. 3
   Filtrationis collected by filtration
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried at 60° C

Vorschrift

A mixture of methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (100 g; 494 mmol), methanol (1 L) and NaOH (6 mol/L in water; 240 mL; 1.44 mol) is refluxed for 3 h. The mixture is allowed to cool to room temperature and then neutralised by addition of hydrochloric acid (6 M in water; ca. 120 mL). Water (200 mL) is added. The precipitate formed is collected by filtration while applying suction, washed with water and dried at 60° C. Yield: 99.6 g (107% of theory).

Quelle