Reaktion #164679

Reaktionsgleichung

Ethyl 4-chloroacetoacetate

2-methyl-2-propanethiol

triethylamine

→

desired product

4-tert-Butylsulfanyl-3-oxo-butyric acid ethyl ester

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONSilica gel was added
2. 2
   Einengenthe mixture was concentrated
3. 3
   Filtrationfiltered over a plug of silica gel

Vorschrift

Ethyl 4-chloroacetoacetate (7.5 mL, 51.9 mmol), 2-methyl-2-propanethiol (5.6 mL, 49.7 mmol), triethylamine (10.8 mL, 77.4 mmol), and catalytic tetrabutylammonium bromide were dissolved in THF (250 mL) and stirred at room temperature overnight. Silica gel was added, and the mixture was concentrated and filtered over a plug of silica gel to obtain the desired product (B-1), which was used without further purification.

Quelle