Reaktion #164270

ord-7e87aa508d2c49488bc7b41343fadb2a

Reaktionsgleichung

Cn1c(-c2cccc(N3CCC[C@H](C(=O)N4CCN(C(=O)OC(C)(C)C)CC4)C3)c2)nc2ccccc21
4-{(S)-1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidine-3-carbonyl}-piperazine-1-carboxylic acid tert-butyl ester
ClCCl
dichloromethane
→
Cl.Cn1c(-c2cccc(N3CCC[C@H](C(=O)N4CCNCC4)C3)c2)nc2ccccc21
title compound
Cl.Cn1c(-c2cccc(N3CCC[C@H](C(=O)N4CCNCC4)C3)c2)nc2ccccc21
{(S)-1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidin-3-yl}-piperazin-1-yl-methanone hydrochloride

Edukte

Cn1c(-c2cccc(N3CCC[C@H](C(=O)N4CCN(C(=O)OC(C)(C)C)CC4)C3)c2)nc2ccccc21
4-{(S)-1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidine-3-carbonyl}-piperazine-1-carboxylic acid tert-butyl ester
ClCCl
dichloromethane

Reagenzien

Keine

Lösungsmittel

Cl
HCl
CCOCC
Et2O

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONwas added
  2. 2
    SonstigeSolvent was removed

Vorschrift

Method A—Step b To a mixture of 4-{(S)-1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidine-3-carbonyl}-piperazine-1-carboxylic acid tert-butyl ester (0.04 g, 0.08 mmol) in dichloromethane (0.5 mL), 2M HCl in Et2O (2 mL) was added and the resulting mixture was stirred overnight at room temperature. Solvent was removed to get 0.04 g of the title compound as hydrochloride salt with quantitative yield.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08835648B2uspto-grants-2014_09