Reaktion #164266

Reaktionsgleichung

5-Chloro-2-[5-(4-ethoxycarbonyl-piperidin-1-yl)-2-fluoro-phenyl]-benzoimidazole-1-carboxylic acid tert-butyl ester

→

title compound

Ausbeute 138.1%

1-[3-(5-Chloro-1H-benzoimidazol-2-yl)-4-fluoro-phenyl]piperidine-4-carboxylic acid hydrochloride

Ausbeute 138.1%

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeSolvent was removed under vacuum
2. 2
   Filtrationthe solid was filtered
3. 3
   Waschenwashed with diethyl ether
4. 4
   Sonstigedried

Vorschrift

Method 10—Step b A mixture of 5-Chloro-2-[5-(4-ethoxycarbonyl-piperidin-1-yl)-2-fluoro-phenyl]-benzoimidazole-1-carboxylic acid tert-butyl ester (0.30 g, 0.60 mmol) in 6N HCl (10 mL) was heated in microwave at 120° C. for 15 minutes, two cycles were needed. Solvent was removed under vacuum, then the solid was filtered and washed with diethyl ether and dried to obtain 0.17 g of the title compound (70%).

Quelle