Reaktion #164152

Reaktionsgleichung

2-phenyl-2-(phenylamino)acetic acid

EDC

HOBt

8-methyl-8-azabicyclo[3.2.1]octan-3-ol

→

title compound

Ausbeute 7.0%

8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-phenyl-2-(phenylamino)acetate

Ausbeute 7.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction is concentrated under reduced pressure
2. 2
   TrocknenThe organic phase is dried over Na2SO4
3. 3
   Filtrationfiltered
4. 4
   Sonstigeevaporated to dryness
5. 5
   SonstigeThe resulting crude is purified by preparative HPLC
6. 6
   SonstigeThe collected compound is partitioned between 1N NaHCO3 and DCM
7. 7
   Sonstigethe organic phase is separated
8. 8
   Trocknendried over Na2SO4
9. 9
   Filtrationfiltered
10. 10
    Sonstigeevaporated under vacuum

Vorschrift

A mixture of 2-phenyl-2-(phenylamino)acetic acid I1 (250 mg, 0.90 mmol), EDC (255 mg, 1.35 mmol), HOBt (245 mg, 1.80 mmol) and 8-methyl-8-azabicyclo[3.2.1]octan-3-ol (380 mg, 2.71 mmol) in dry DMF (10 mL) is heated under microwave irradiation at 100° C. for 1 hour (LC-MS monitoring: complete conversion). The reaction is concentrated under reduced pressure and the residue is portioned between EtOAc and water. The organic phase is dried over Na2SO4, filtered and evaporated to dryness. The resulting crude is purified by preparative HPLC. The collected compound is partitioned between 1N NaHCO3 and DCM, the organic phase is separated dried over Na2SO4, filtered and evaporated under vacuum to give 20.1 mg of the title compound as a colorless oil (7% yield, mixture of diastereoisomers).

Quelle